Tuesday, March 4, 2008

Agricultural Biotechnology

Agricultural Biotechnology
The low efficiency of current microinjection-based animal transgenesis ... mediated transgenesis with RecA:ssDNA complexes during pig and goat transgenesis ...

Molecular Therapy - Real-Time in Vivo Imaging of Stem Cells ...

Molecular Therapy - Real-Time in Vivo Imaging of Stem Cells ...
To confirm that transgenesis occurred by transposition into the genome of MAPC, ... Cells were incubated sequentially in primary goat anti-Luciferase-Biotin ...

Activation of CD4 T Cells by Somatic Transgenesis Induces ...

Activation of CD4 T Cells by Somatic Transgenesis Induces ...
Activation of CD4 T Cells by Somatic Transgenesis Induces Generalized .... The wells were then incubated for 1 h at room temperature with a goat Ab to mouse ...

Theriogenology : Recombinase-mediated mouse transgenesis by ...

Theriogenology : Recombinase-mediated mouse transgenesis by ...
The low efficiency of current microinjection-based animal transgenesis ... mediated transgenesis with RecA:ssDNA complexes during pig and goat transgenesis ...

Monday, March 3, 2008

Is genetically-modified rice the solution to Vitamin A deficiency?

Genetic engineering (GE) in agriculture is a controversial topic in science and society at large. While some oppose genetically modified crops the question remains whether GE can benefit the poor.

Golden Rice has been genetically engineered to produce provitamin A. The technology is still in the testing phase, but, once released, the authors expect to address one consequence of poverty – vitamin A deficiency (VAD) – and its health implications. Current interventions to combat VAD rely mainly on pharmaceutical supplementation, which is costly in the long run and only partially successful.

In order to evaluate the potential benefits of Golden Rice, the authors built a nationally representative data set of household food consumption in India.

Main findings and conclusions:

  • India’s annual burden of VAD of can be reduced by 59.4% if Golden Rice would be consumed widely
  • saving one healthy life year through Golden Rice could cost as little as US$3.06 – or about Rs.140, which is less than a week’s earning of a poorly paid rural day labourer
  • the cost per ‘healthy life year’ saved through Golden Rice is lower than the cost of current supplementation efforts, and it outperforms international cost-effectiveness thresholds
  • given the complex nature of the problem and the complementary characteristics of the different micronutrient interventions, Golden Rice is not a ‘cure-all’ in the fight against VAD
  • to realise the potential of Golden Rice pro-active and targeted implementation of R&D and dissemination activities, as well as broad public support, would be needed.

Is Africa rejecting genetic engineering in food and agriculture?

This booklet outlines recent key trends, developments and actors in the debate on genetic engineering (GE) in food and agriculture in Africa. It also highlights a number of the key talking points including the harmonisation of bio-safety legislation, the new green revolution in Africa, and genetic diversity.

It is argued that more than 10 years have passed since Genetically Modified Organisms (GMOs) were first commercialised in the world, yet out of more than 50 African countries, only South Africa has explicitly taken bio-safety decisions to authorise the commercial cultivation and importation of GMOs for the purposes of food, feed and processing.

Key points highlighted throughout recent trends include:

  • several African countries such as Sudan, Angola and Zambia have fiercely resisted receiving GM food aid, precipitating reforms in food aid policies internationally
  • the GM push in Africa has recorded several significant setbacks and failures, with Florence Wambugu’s GM sweet potato in Kenya and the Gates Foundation’s GM sorghum in South Africa being the most prominent
  • this rejection represents a huge set back for crucial components of the ‘New Green Revolution in Africa’ push, which is heavily funded by the Gates Foundation
  • 2007 has not been a good year for GE in South Africa. The first ever GM cassava field trials also faced the thumbs down from the South African regulatory authorities
  • while the GE lobby has waged a heavily resourced battle for acceptance of GMOs, public reaction has in many instances been hostile. The media has been extremely critical of GMOs in countries such as Kenya, Zambia and South Africa.

Sunday, March 2, 2008

Theriogenology : Recombinase-mediated mouse transgenesis by ...

The low efficiency of current microinjection-based animal transgenesis ... mediated transgenesis with RecA:ssDNA complexes during pig and goat transgenesis ...

Activation of CD4 T Cells by Somatic Transgenesis Induces ...

Activation of CD4 T Cells by Somatic Transgenesis Induces Generalized .... The wells were then incubated for 1 h at room temperature with a goat Ab to mouse ...

Molecular Therapy - Real-Time in Vivo Imaging of Stem Cells ...

To confirm that transgenesis occurred by transposition into the genome of MAPC, ... Cells were incubated sequentially in primary goat anti-Luciferase-Biotin ...

Gene therapy speeds transgenic animal production

In-PharmaTechnologist.com - London,UK
To produce the larger transgenic animal, radiation was first used to kill a section of the male goat's germ cells. A modified AAV was then used to insert a ...
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